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Historically, women have lived longer than men in almost every country in the world. A similar pattern of sex differences in longevity is also found in many other species; however, it is not clear if there are more species in which females live longer or vice versa. For virtually all the primary causes of death and at virtually all ages, mortality rates are higher for men. Women do not live longer than men because they age more slowly, but because they are more robust at every age. Paradoxically, although women have lower mortality rates they have higher overall rates of physical illness than do men.

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Exogenous sex steroids are likely to affect LDL metabolism via effects on the LDL receptor; Estrogens increase LDL receptor activity in non-human species at both the hepatic cellular and mRNA levels, though this is yet to be confirmed in humans ;??

Androgens decrease LDL receptor activity yet to be tested in either human or non-human species. Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 2.

Links to PubMed are also available for Selected References.

Why do women live longer than men?

These references are in PubMed. This may not be the complete list of references from this article. National Center for Biotechnology InformationU. Trans Am Clin Climatol Assoc. Hazzard and D. Author information Copyright and information Disclaimer. Copyright notice. This article has been cited by other articles in PMC. Abstract 1.

Why women live longer than men: the biologic mechanism of the sex differential in longevity.

Hazzard WR. Biological basis of the sex differential in longevity. J Am Geriatr Soc. Aging, natural death, and the compression of morbidity.

N Engl J Med. Health promotion and the compression of morbidity. A life table for the common house fly, Musca domestica.

Why women live longer than men: sex differences in longevity

Differential mortality by sex in fetal and neonatal deaths. The sex differential in morbidity, mortality, and lifestyle. Annu Rev Public Health. Can smoking explain ultimate gender gap? Oral contraceptive and postmenopausal estrogen effects on lipoprotein triglyceride and cholesterol in an adult female population: relationships to estrogen and progestin potency.

J Clin Endocrinol Metab. Serum high-density-lipoprotein cholesterol in women using oral contraceptives, estrogens and progestins. Influence of gonadal hormones on protein-lipid relationships in human plasma. Am J Med. Metabolic and hormonal effects of post-menopausal oestrogen replacement treatment.

Plasma lipids.

Acta Endocrinol Copenh Nov; 86 3 — Effects of different progestogens on lipoproteins during postmenopausal replacement therapy. Sex, plasma lipoproteins, and atherosclerosis: prevailing assumptions and outstanding questions. Am Heart J. Menopause and risk factors for coronary heart disease.

Cardiovascular mortality and noncontraceptive use of estrogen in women: from the Lipid Research Clinics Program Follow-up Study. Menopausal oestrogen therapy and protection from death from ischaemic heart disease.

A prospective study of postmenopausal estrogen therapy and coronary heart disease. Postmenopausal estrogen use, cigarette smoking, and cardiovascular morbidity in women over The Framingham Study. High-density lipoprotein and coronary heart-disease: a prospective case-control study. Lipoprotein substrates of lipoprotein lipase and hepatic triacylglycerol lipase from human post-heparin plasma.

Biochim Biophys Acta.

Why do women live longer than men? it's more complicated than you think.

Hydrolysis of human plasma high density lipoprotein 2- phospholipids and triglycerides by hepatic lipase. Biochem Biophys Res Commun. High density lipoproteins during hypolipidemic therapy. A comparative study of four drugs. Reduction in high density lipoproteins by anabolic steroid stanozolol therapy for postmenopausal osteoporosis.

Studies on the metabolic mechanism of reduced high density lipoproteins during anabolic steroid therapy.

Stanozolol in postmenopausal osteoporosis: therapeutic efficacy and possible mechanisms of action. The dyslipoproteinemia of anabolic steroid therapy: increase in hepatic triglyceride lipase precedes the decrease in high density lipoprotein2 cholesterol. Preliminary report: kinetic studies on the modulation of high-density lipoprotein, apolipoprotein, and subfraction metabolism by sex steroids in a postmenopausal woman.

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E. J Biol Chem. Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.

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While it's long been known that women tend to live longer than men, researchers for years ascribed the trend to lifestyle differences.

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Everywhere in the world women live longer than men — but this was not always the case.